**Research Group Overview**

The research direction of Huang Shengbin's research group mainly focuses on the mitochondrial molecular mechanism of the occurrence and development of oxidative stress-related oral diseases and the prevention and treatment strategies.

**Research Areas**

1. Research on the mitochondrial molecular mechanism and the prevention and treatment strategy of periodontitis.

2. Research on the mitochondrial molecular mechanism of the bone development and related diseases and the prevention and treatment strategies.

3. Biomechanics and clinical research of oral prosthesis. 

**Head of the Group**

Professor Huang Shengbin, vice president of Stomatological Hospital affiliated to Wenzhou Medical University, leader of the research group. 

**Personal Profile**

Personal profile: Huang Shengbin, Doctor of Clinical Dentistry, Professor/Deputy Chief Physician, Doctoral Supervisor, Visitor of Dental Center of University of Kansas and University of Amsterdam, Netherlands; School of Stomatology, Wenzhou Medical University. Vice President of Affiliated Stomatological Hospital. Fellow of International College of Dentists, Special Committee on Oral Medicine Education of Chinese Stomatological Association, Special Committee on Oral Hereditary Diseases and Rare Diseases and Special Committee on Oral Aesthetics; Presided over 12 scientific research projects, such as National Natural Science Foundation of China and Youth Foundation, Outstanding Youth Fundation of the Natural Science Foundation of Zhejiang Province, and Joined Major Projects of Zhejiang Provincial Ministry of Medical Health Science and Technological Plan, published more than 50 SCI papers (first author/co-first author/corresponding author), participated in 3 monographs, applied for and authorized 4 patents. At the same time, he has presided over the first-class course "Oral and Health" in Zhejiang Province. He has been selected as the winner of The Outstanding Youth Fund of Zhejiang Province Natural Science Found, Young Top-Notch Talents of Zhejiang Province "Ten Thousand Talents Program", Health Innovative Talents Training Objects of Zhejiang Province, University Top-Notch Talents of Zhejiang Province, Medical Rookie of Zhejiang Province, and the "Academician Pair Youth Talent Training Program" of the Association for Science and Technology of Zhejiang Education Department and other talent projects. He won the third prize of Zhejiang Science and Technology Progress Award (mainly completed person) and the first prize of IADR-PPRS. 

School of Stomatology affiliated to Wenzhou Medical University

Address: Dental Laboratory, Xueyuan Road Campus, Wenzhou Medical University, Lucheng District, Wenzhou, Zhejiang Province

Tel: +86-0577-88066060

Email: huangsb003@wmu.edu.cn.

**Members**

The group includes several researchers including attending dentistry Mao Yixin, resident dentitry Chen Yang, doctor Li Bin ,Ping Yifan, Chen Yumin, postgraduates Hu Chaoming, Zhang Yichi, Jiang Tianle.

**Representative papers in the last three years**

**Basic research**

**Molecular biology**

1. Sun X, Ping Y, Li X, Mao Y, Chen Y, Shi L, Hong X, Chen L, Chen S, Cao Z, Chen P, Song Z, Wismeijer D, Wu G, Ji Y,  Huang S. Activation of PGC-1α-dependent mitochondrial biogenesis supports therapeutic effects of silibinin against type I diabetic periodontitis. J Clin Periodontol. 2023 Jul; 50(7):964-979. (corresponding author)

2. Jiang W, Wang Y, Cao Z, Chen Y, Si C, Sun X, Huang S. The role of mitochondrial dysfunction in periodontitis: From mechanisms to therapeutic strategy. J Periodontal Res. 2023 Oct; 58(5):853-863. (corresponding author)

3. Shi L, Ji Y, Zhao S, Li H, Jiang Y, Mao J, Chen Y, Zhang X, Mao Y, Sun X, Wang P, Ma J,  Huang S. Crosstalk between reactive oxygen species and Dynamin-related protein 1 in periodontitis. Free Radic Biol Med. 2021, 172: 19-32. (corresponding author)

**Biomechanics**

1. Chen S, Ye Z, Hong X, Chen L, Wu L, Wang Y, Chen Y, Wu M, Wang J, Zhang Q, Wu Y, Sun X, Ding X, Huang S,  Zhao S. The effect of periapical bone defects on stress distribution in teeth with periapical periodontitis: a finite element analysis. BMC Oral Health. 2023 Dec 8; 23(1):980. (Co-corresponding author)

2. Chen S, Hong X, Ye Z, Wu M, Chen L, Wu L, Wang Y, Chen Y, Wu J, Wang J, Zhang Q, Wu Y, Sun X, Ding X, Huang S,  Zhao S. The effect of root canal treatment and post-crown restorations on stress distribution in teeth with periapical periodontitis: a finite element analysis. BMC Oral Health. 2023 Dec 6; 23(1):973. (Co-corresponding author)

3. Mao J, Wang L, Jiang Y, Cheng H, Li N, Shi S, Fan F, Ma J,  Huang S. Nanoscopic wear behavior of dentinogenesis imperfecta type II tooth dentin. J Mech Behav Biomed Mater. 2021, 120: 104585. (Corresponding author)

**Biological materials**

1. Han Y, Tong X, Zhou R, Wang Y, Chen Y, Chen L, Hong X, Wu L, Lin Z, Zhang Y, Zhang X, Hu C, Li B, Ping Y, Cao Z, Ye Z, Song Z, Li Y, Wen C, Zhou Y,  Lin J,  Huang S. Biodegradable Zn-5Dy alloy with enhanced osteo/ angio-Genic activity and osteointegration effect via regulation of SIRT4-dependent mitochondrial function. Adv Sci (Weinh). 2024 Jan 19: e2307812. (Corresponding author)

2. Tong X, Wang H, Zhu L, Han Y, Wang K, Li Y, Ma J, Lin J, Wen C, Huang S. A biodegradable in situ Zn-Mg2Ge composite for bone-implant applications. Acta Biomater. 2022 Jul 1; 146:478-494. (Corresponding author)

3. Zheng X, Zhang X, Wang Y, Liu Y, Pan Y, Li Y, Ji M, Zhao X, Huang S,  Yao Q. Hypoxia-mimicking 3D bioglass-nanoclay scaffolds promote endogenous bone regeneration. Bioact Mater. 2021, 6(10): 3485-3495. (Co-corresponding author)

**Clinical research**

1. Wang J, Hu C, Ma X, Zhang Y, Zhang X, Hong X, Chen L, Wang Y, Wang J, Chen S, Zhang Q, Wu Y, Wu M, Chen Y, Song Z, Sun X, Zhao S,  Huang S. The role of oxidative stress biomarkers in the development of peri-implant disease: A systematic review and meta-analysis[J]. J Dent, 2024, 146: 105026. (Corresponding author)

2. Wang J, Chens S, Wu Y, Zhang Q, Wu M, Chen Y, Chen L, Hong X, Wang Y,  Huang S. The influence of Erbium Laser pretreatment on dentin shear bond strength and bond failure modes: A systematic review and network meta-analysis. J Adhes Dent. 2024 Jan 15; 26(1):147-170. (Corresponding author)

3. Shi S, Li N, Jin X, Huang S,  Ma J. A digital asthetic rehabilitation of a patient with dentinogenesis imperfecta Type II: A clinical report. J Prosthodont. 2020, 29(8): 643-650. (Co-corresponding author)

**English monographs**

1. Nanomaterials in Clinical Dentistry,2012,Elsevier (English, Participated)

Chinese monographs:

1. Complete Denture, 2021, People's Health Publishing House

2. Oral Biomechanics, 2012, People's Health Publishing House (secretary and editor)

**Patents Applied For**

1. An adjustable occlusal pad, ZL 2017 2 0822667.9 Huang Shengbin, Julie, Wang Lin, Li Ning, Sun Xiaoyu.

2. A mouth gag with a mask, ZL 2017 2 0819981.1 Huang Shengbin, Li Ning, Julie, Wang Lin and Sun Xiaoyu.

3. An adjustable occlusal plane guide plate, ZL 2018 1 0066045.7 Huang Shengbin, Ma Jianfeng, Wang Siqian, Mao Yixin and Julie.

4. Use of 3-methylindole Dimethylamino Dithioester in the preparation of drugs for preventing and treating periodontitis, ZL 20221129632.9, Huang Shengbin, Jiang Yun, Ren Xuekun, Mao Jiajie.

5. Degradable in-situ Mg:Ge particle reinforced Zn-based composite and its preparation method, ZL 2022 1 0053889.4, Huang Shengbin, Tong Xian, Lin Jixing, Julie, Ma Jianfeng.

**Projects hosted by the research group in the past three years:**

1. General project of National Natural Science Foundation of China, Study on the Role and Mechanism of Mitochondrial Function Control Axis of MST1/VDAC1 in Periodontitis, 2023-01 to 2026-12.5 million yuan, under research and presided over.

2. Natural Science Foundation of Zhejiang Province, Outstanding Youth Science Fund Project, R21H140003, Study on the Mechanism of Mitochondrial Dysfunction Mediated by Trpm2/PGAM5 to Promote Periodontitis, 2021-01 to 2023-1280,000 yuan, ending and presiding.

3. Scientific Research Fund of National Health and Wellness Committee-Zhejiang Medical and Health Major Science and Technology Plan (a major project jointly established by the province and the Ministry), construction of a new injectable multifunctional temperature-sensitive hydrogel and its application research in the prevention and treatment of periodontitis, 2023-01 to 2025-12.5 million yuan, under research and presided over.

4. Wenzhou Science and Technology Bureau, social development (medical and health) science and technology project, ZY2021015, construction of multifunctional drug-loaded supramolecular hydrogel and its application research in periodontitis prevention and treatment, 2022-01 to 2024-12.5 million yuan, under research, presided over.

**Contact Us**

Recruitment of Huang Shengbin Research Group, School of Stomatology Affiliated to Wenzhou Medical University

**Brief introduction of the research group**

Team leader: Huang Shengbin, Doctor of Clinical Dentistry, Professor/Deputy Chief Physician, Doctoral Supervisor, Visitor of Dental Center of University of Kansas and University of Amsterdam, Netherlands; School of Stomatology, Wenzhou Medical University. Vice President of Affiliated Stomatological Hospital. Fellow of International College of Dentists, Special Committee on Oral Medicine Education of Chinese Stomatological Association, Special Committee on Oral Hereditary Diseases and Rare Diseases and Special Committee on Oral Aesthetics; Presided over 12 scientific research projects, such as National Natural Science Foundation of China and Youth Foundation, Outstanding Youth Fundation of the Natural Science Foundation of Zhejiang Province, and Joined Major Projects of Zhejiang Provincial Ministry of Medical Health Science and Technological Plan, published more than 50 SCI papers (first author/co-first author/corresponding author), participated in 3 monographs, applied for and authorized 4 patents. At the same time, he has presided over the first-class course "Oral and Health" in Zhejiang Province. He has been selected as the winner of The Outstanding Youth Fund of Zhejiang Province Natural Science Found, Young Top-Notch Talents of Zhejiang Province "Ten Thousand Talents Program", Health Innovative Talents Training Objects of Zhejiang Province, University Top-Notch Talents of Zhejiang Province, Medical Rookie of Zhejiang Province, and the "Academician Pair Youth Talent Training Program" of the Association for Science and Technology of Zhejiang Education Department and other talent projects. He won the third prize of Zhejiang Science and Technology Progress Award (mainly completed person) and the first prize of IADR-PPRS.

Research direction:

1. Research on the mitochondrial molecular mechanism and the prevention and treatment strategy of periodontitis.

2. Research on the mitochondrial molecular mechanism of the bone development and related diseases and the prevention and treatment strategies.

3. Biomechanics and clinical research of oral prosthesis.

Postdoctors and researchers with professional backgrounds in cell biology and materials science are urgently needed to join. Treatment liberally.