Email 中文版
Introduction to the research group
Deng Hui's research group focused on the role and molecular mechanism of Porphyromonas gingivalis in the relationship between periodontitis and cardiovascular disease from the perspective of clinical key issues for a long time, and clarified the molecular mechanism and new prevention and treatment strategies of Porphyromonas gingivalis promoting atherosclerosis around endothelial dysfunction. In addition, it focuses on the integration and innovation of oral medicine and biomaterials, devotes itself to the research on the application and strategy of intelligent hybrid hydrogel and nano drug sustained release system in the prevention and treatment of chronic periodontitis, uses hybrid hydrogel and interdisciplinary advantages to assist photothermal and antioxidant treatment to solve the difficulties and pain points of traditional periodontitis treatment, and breaks through the bottleneck of traditional drug treatment.
Research field
1. The role and molecular mechanism of Porphyromonas gingivalis in the correlation between periodontitis and cardiovascular disease;
2. The application and strategy research of hydrogel and nano drug sustained release system in the treatment of chronic periodontitis and tissue defect repair;
Leader of the research group
Dr. Deng Hui, the leader of the research project,
the chief physician and vice president of the Department of Periodontology at the School & Hospital of Stomatology Wenzhou Medical University
Deng Hui, Chief Physician, Master's Supervisor, and vice president of the Department of Periodontology at the School & Hospital of Stomatology Wenzhou Medical University. Graduated from Sichuan University with a PhD in Oral Clinical Medicine. Visiting scholar at the University of Washington and the University of Queensland. The team is clinically committed to the standardized multidisciplinary diagnosis and treatment of moderate and severe periodontitis, and scientific research is committed to the role and molecular mechanism of Porphyromonas gingivalis in the correlation between periodontitis and cardiovascular disease, periodontal intelligent drug delivery solution gel and nano drugs to prevent and treat periodontitis. Served as a standing committee member of the Periodontology Special Committee of the Chinese Stomatological Association and vice chairman of the Periodontology Special Committee of the Zhejiang Stomatological Association. The team has led 20 scientific research projects, including 3 National Natural Science Foundation projects and 5 basic public welfare projects in Zhejiang Province. Published 43 high-level papers as the first or corresponding author, cited 1032 times, 1 paper selected as ESI highly cited paper, authorized 3 national invention patents as the first inventor, participated in the compilation of translations by the National Health Commission and textbooks for vocational colleges in the 14th Five Year Plan. Selected as Zhejiang Province Health Innovation Talents, Wenzhou Ouyue Talent Plan - Wenzhou Famous Doctors, Zhejiang Province Medical Newcomer, and Zhejiang Province Young and Middle aged Discipline Leaders in Universities.
School & Hospital of Stomatology Wenzhou Medical University
Address: Institute of Stomatology, East Teaching Building, Xueyuan Road Campus, Wenzhou Medical University, No. 1288 Longyao Avenue, Longwan District, Wenzhou City (Longwan General Hospital)
Phone: 0577-88066030
Email: dh0726@163.com
Member
Cai Xiaojun, PhD, Researcher School & Hospital of Stomatology Wenzhou Medical University Email: cxj20032284@wmu.edu.cn |
Wang Yi, Ph.D., Associate Professor Email: y.wang@wmu.edu.cn |
Hou Yubo, Ph.D., Lecturer |
Mu Zhixiang, Resident Physician, Email: 252218948@qq.com |
He Linlin, Ph.D., Lecturer |
Xing Zhenjie, Resident Physician School & Hospital of Stomatology Wenzhou Medical University Email: 894037614@qq.com |
Zeng Bairui, Resident Physician School & Hospital of Stomatology Wenzhou Medical University Email: 1160574686@qq.com |
Xu Shengming, graduate student School & Hospital of Stomatology Wenzhou Medical University Email: xushengming0928@163.com |
Huang Jianmin, graduate student School & Hospital of Stomatology Wenzhou Medical University Email: 1361658420@qq.com |
Zheng Cheng, graduate student School & Hospital of Stomatology Wenzhou Medical University Email: 1192078712@qq.com |  Hu Jiajun, graduate student School & Hospital of Stomatology Wenzhou Medical University Email: hu81333262@126.com |
Ge Xinxin, graduate student School & Hospital of Stomatology Wenzhou Medical University Email: 757182368@qq.com |
Lu Bin, graduate student School & Hospital of Stomatology Wenzhou Medical University Email: 1515708413@qq.com |
Que Hanxin, graduate student School & Hospital of Stomatology Wenzhou Medical University Email: 1098520097@qq.com |
Yu Li, graduate student School & Hospital of Stomatology Wenzhou Medical University Email: 974969226@qq.com |
Shi Yizuo, graduate student School & Hospital of Stomatology Wenzhou Medical University Email: zrsdrt210@163.com |
Research findings
近年代表性论文：
1. Wang Y, Chu T, Jin T, Xu S, Zheng C, Huang J, Li S, Wu L, Shen J, Cai X, Deng H. Cascade Reactions Catalyzed by Gold Hybrid Nanoparticles Generate CO Gas Against Periodontitis in Diabetes. Adv Sci (Weinh). 2024 Jun;11(24):e2308587.
2. Cai E, Qi X, Shi Y, Ge X, Xiang Y, Xu H, Li Y, Lan Y, Shen J, Hu R, Deng H. TI Immunomodulatory melanin@Pt nanoparticle-reinforced adhesive hydrogels for healing diabetic oral ulcers. Chemical Engineering Journal. 2024 MAY 15;488:150372.
3. Mu Z, Shen T, Deng H, Zeng B, Huang C, Mao Z, Xie Y, Pei Y, Guo L, Hu R, Chen L, Zhou Y. Enantiomer-Dependent Supramolecular Immunosuppressive Modulation for Tissue Reconstruction. ACS Nano. 2024 Feb 13;18(6):5051-5067.
4. Ye L, He X, Obeng E, Wang D, Zheng D, Shen T, Shen J, Hu R, Deng H. The CuO and AgO co-modified ZnO nanocomposites for promoting wound healing in Staphylococcus aureus infection. Mater Today Bio. 2023 Jan 14;18:100552.
5. SY You, YJ Xiang, XL Qi, RT Mao, EY Cai, YL Lan, HY Lu, JL Shen，H Deng. Harnessing a biopolymer hydrogel reinforced by copper/tannic acid nanosheets for treating bacteria-infected diabetic wounds. Materials Today Advances, 2022, August,15:100271.
6. Deng H, Gong Y, Chen Y, Zhang G, Chen H, Cheng T, Jin L, Wang Y. Porphyromonas gingivalis lipopolysaccharide affects the angiogenic function of endothelial progenitor cells via Akt/FoxO1 signaling. J Periodontal Res. 2022 Jun 13.
7. Yi Wang; H. N. Liu; Zhe Zhen; George Pelekos; Mei Zhen Wu; Yan Chen; Maurizio S. Tonetti;,Hung-Fat Tse; Kai-Hang Yiu; Lijian Jin ; A randomized controlled trial of the effects of non‐surgical periodontal therapy on cardiac function assessed by echocardiography in type 2 diabetic patients, Journal of Clinical Periodontology, 2020, 47(6): 726-736.
8. Yi Wang; Zhe Zhen; H. N. Liu; Ian Lai; George Pelekos; Hung-Fat Tse; Kai-Hang Yiu; Lijian Jin ; Periodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes, Journal of Periodontal Research, 2019, 54(4): 339-348.
9. Mehwish N, Chen Y, Zaeem M, Wang Y, Lee BH, Deng H. Novel biohybrid spongy scaffolds for fabrication of suturable intraoral graft substitutes. Int J Biol Macromol. 2022 Jun 23;214:617-631.
10. Pan W, Qi X, Xiang Y, You S, Cai E, Gao T, Tong X, Hu R, Shen J, Deng H. Facile formation of injectable quaternized chitosan/tannic acid hydrogels with antibacterial and ROS scavenging capabilities for diabetic wound healing. Int J Biol Macromol. 2022 Jan 15;195:190-197.
11. He Z, Zhou X, Wang Y, Lin J, Huang S, Hu R, Zhou Y, Qian Q, Deng H. Asymmetric barrier membranes based on polysaccharide micro-nanocomposite hydrogel: Synthesis, characterization, and their antibacterial and osteogenic activities. Carbohydr Polym. 2021 Dec 1;273:118525.
Chinese monograph:
1. Oral Medicine, People's Health Press, ISBN 978-7-117-29259-7, Textbook for the 14th Five Year Plan for Higher Vocational Education, November 2021
Patent application:
1. Ultra long acting controllable slow-release mesoporous hyaluronic acid hybrid targeted antibacterial nanomaterials and their preparation methods, applications (Patent No. ZL 2021 1 0753763.3)
2. Application of monocarbonyl curcumin compounds in the preparation of drugs for the prevention and treatment of periodontitis (Patent No. ZL 2021 1 0181046.8)
3. Preparation method and application of a multifunctional GTR gradient barrier membrane (patent number ZL 2018 1 1587340.3)
Project led by the research group:
1. Deng Hui, National Natural Science Foundation of China General Project (82470990), "Mechanism Study of ATP6V0d2 Regulating Mitochondrial Autophagy Flow through STX17-VAMP8 in Pg Induced Endothelial Dysfunction", 2025.1-2018.12, 490000
2. Deng Hui, Young Scientists Fund of the National Natural Science Foundation of China (81200795), "Influence of Porphyromonas gingivalis infection on the journey of monocyte derived foam cells and its mechanism", 2012.1-2015.12, 220000 yuan
3. Wang Yi, National Natural Science Foundation of China Youth Science Fund Project (82101029), Study on the Effect and Mechanism of Porphyromonas gingivalis Inhibiting Endothelial Progenitor Cells on Damaged Vascular Reendothelization by Activating FOXO1, January 1, 2022 to December 31, 2024, 300000
4. Deng Hui, Zhejiang Provincial Natural Science Foundation General Project (LY12H14003), "Effects and Mechanisms of Porphyromonas gingivalis Lipopolysaccharide on Endothelial Cell Adhesion Function", 2012.1-2014.12, 80000
5. Wang Yi, General Project of Zhejiang Natural Science Foundation (LQ2H2H140002), Study on the Dysfunction and Molecular Mechanism of Endothelial Progenitor Cells Induced by Porphyromonas gingivalis Infection, 2020.01-2022.12, 90000
6. Deng Hui, Zhejiang Provincial Natural Science Foundation General Project (LY17H140007) "The Role and Regulatory Mechanism of TAZ Cbf α 1 Axis and Its Upstream Signaling Pathway in Stress Induced Periodontal Membrane Cell Bone Phase Differentiation", January 2017 December 2019, 80000
7. Deng Hui, Zhejiang Public Welfare Technology Research Program (LGF21H140006)“ PDA@Curdlan Construction of intelligent responsive hydrogel drug controlled release system and photothermal synergistic antibacterial application ", 2021.1-2023.1231, 100000
8. Deng Hui, Wenzhou Major Science and Technology Innovation Project (ZY2022020) "Construction and Prevention of Periodontitis with Dual Responsive Polymer Nanovesicle Delivery System Based on NO Gas Antibacterial Strategy", 2023.1-2025.12, 300000 yuan
